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Edit: That and if you fought another deadly sin, then he wouldn't show up on that floor or the next floor, either (I think).
Kind of off-topic, but sometimes you get those games where you get several rooms in a row of just constant Greeedheads. They're annoying because their shots are so hard to avoid, but not as annoying as the actual Greed. Just seeing him means you both wasted a key and you have to waste time fighting him.
"Greed has a chance of appearing in any shop from the Caves/Catacombs 2 onwards. He will spawn in the Caves/Catacombs 2 shop with a 50% chance and always spawn in the shop after that, unless he spawned in the previous floor, spawned in the Secret Room (which happens from the Depths 1 onwards with a 33% chance) or a different Sin is going to appear in that level.
If you have obtained only The Compass but not the Treasure Map, you are able to spot Greed if he is in the Secret Room, since then there's a miniboss icon that won't reveal a grey room icon in the background even when you get next to it. Once you obtain the Treasure Map (or approach the room with Spelunker Hat or X-Ray Vision), the miniboss icon will disappear and you will see the icon for the Secret Room as usual, yet it will still contain Greed.
Only one of the Seven Deadly Sins can appear on a floor in their own designated room, meaning that if the player has already fought one of the Seven Sins in a room marked on the map, Greed will not appear in the Shop or Secret Room."
http://bindingofisaac.wikia.com/wiki/Greed
Basically, the best way to avoid him is to learn his spawn mechanics and hope that the RNG is on your side. Hopefully this helps somewhat, but again, I am unsure how much of this still applies in Rebirth.
You would think they would at least make Greed and Super Greed share the one-floor cooldown.
EDIT:
I'm also Greedless on a majority of my runs, but only because I don't enter shops past the third floor on a majority of my runs.
That's actually a really good gameplay tip. I should keep that in mind when I have at least 5 coins.