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beating mom's heart in less than 20 minutes
Boss Rush isn't too difficult, if you were to compare it to Sheol or The Cathedral, but it can be pretty hard without a lot of damage (health isn't much of a big issue as long as you've got at least 4 regular hearts due to the fact that hearts will be spawning all over the place.)
If you haven't, I can see why it might be a threat...
Though the room always tends to have really good items that makes it worth it, for me anyway like one time I had brimstone + Quad shot + 20/20 + Loki's horns. That was a good run
Sometimes it's a better idea to save a card/pill that teleports you, go to the boss rush room, take the item you want and leave.
It really all depends on your luck and what items you get.
Bingo. Though mom's knife REALLY helps ;) - think they should lower the time limit to get Boss Rush to half an hour instead of twenty mins though -_-.