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If you SEE a special item, the chance of seeing another special item is significantly reduced, except if a character starts with it (Isaac/Eden)
-Is there still any way to cheese a seed run into giving you real unlocks?
Nope, it was patched
-Can Eden start with Godhead and have that count as obtaining it? Or does it need to be picked up manually the old fashioned way first?
Yes it works, and you can also reroll your build by using dice room/D4/D100.
Good job man, the game sure is a grind to TPG, but after you get everything, you're left with just the fun of not having to worry about re-rolling every item you see hoping to get what you need.