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There are two types of blood bags. The first blood bag which looks like a full blood bag gives you increased hp and heals you if you have taken damage. The second blood bag is actually called an IV bag and looks half full, with a needle. That one is a spacebar item that acts like a blood donor machine that gives you money in return.
Passive item: http://bindingofisaacrebirth.gamepedia.com/Blood_Bag