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first treasure room - tech x
second treasure room - monstro's lung
depths I boss - Cthulu
depths II arcade room beggar - bumbo
Game Breaking Seed: Restock + 2 Steam Sales
Basement I Tresure Room: Tech X
Burning Basement II Shop: Restock
Caves I: IMPORTANT Reroll Treasure Room Item until appear Pay To Play, take it or reroll
Shop: Steam Sale and Sackhead
Catacombs II: Challenge Room with Goat Head
Dephts I: Second Steam Sale after kill Greed in the Secret Room
Have fun ;)
Start on XL floor, Proptosis + Tech X in item rooms, Pentagram in devil room.
12WT 167T, hard mode
Death's Touch + Cricket's Body is pretty strong. Using the 5 dice room to reroll necropolis 2 gives you pupula duplex in the treasure room if you bought more options earlier on. There is a Head of the Keeper fairly early on but i cant remember where. The chest has curse of the blind but there's inner eye and chocolate milk in there somewhere.
Not extremely op, but a fun (read: doable) run for keeper! I didn't make boss rush or blue womb so no idea what those are like.
(you need to go to chest)
4DW4 VN6W
( You can play as Isacc and Reroll unwanted Rewards to becoming even more lunatic )
Seed: TFQ3RPA9 Greed Mode
Chocolate Milk - Grants charged tears that deal greater damage when fully charged. Tear damage scales from approximately 30% damage at minimum charge to 400% damage at full charge.
Mutant Spider - Grants a quadruple shot.
The Inner Eye - Grants a triple shot.
The Parasite - Tears turn sickly brown and split on impact with walls or enemies.
Spirit of the Night - Grants spectral tears and flight.
https://www.youtube.com/watch?v=tPVr1qX6Yaw
And Stopwatch + Holy Mantle for good measure. Oh and Inner Eye, if you start as Eden.
No single DMG UP, in fact, i had way less DMG at the end of the run, thanks to Tech 2, (DMG stat was 1) yet it was one of the easiest, most overpowered builds, i've had. Man, Spoonbender wouldn've made it perfect, tho.
The first Devil Room (floor 2) is a bust (Kramp-O), but the one on floor 4 and beyond have what your heart so desires. Thanks to good old Krampus, you may end up with an Angel Room run instead, so fingers crossed.
Seed/Afterbirth: 37GG TVYN
And high stats up the wazoo.
Pretty much the single most powerful run i ever had so far - Tammy's Head/Brimstone ain't got shiznit on this (Fun fact, you can find Tammy's Head and Brimstone in this seed as well, if that's what floats your boat).
Boss Rush? 20 seconds tops. Hush? Like 30 Seconds. Everything else's death can be missed by blinking. Thanks to Tractor beam + Continuum, instead of your shots coming out from the other side of the room, they'll re-appear right in front of your face and quickly stack up.
Here's an appetizer:
http://steamcommunity.com/sharedfiles/filedetails/?id=611098830
http://steamcommunity.com/sharedfiles/filedetails/?id=611098760
Re-Roll the first floor's Item room to get Tractor Beam and the first floor's boss item into Squeezy. Upon entering floor 2, go up for a Golden Chest containing Cricket's Head. Proprosis will wait for you in the treasure room and Death's Touch on the same floor's devil room. Pick up Guppy's Paw as well, then re-roll it to get Lord of the Pit.
Make sure you keep 5 coins on you, before entering the 6th floor to get an arcade to spawn. It will be a few rooms before the Mom-fight. Blow up the fortune-teller in there for Cancer.
The second Guppy-item will be the 4th floor's devil room, alongside Abaddon. If you wanna become Guppy, there's a devil room with 3 items either on Womb 1 or 2, which you need to re-roll.
Seed/Afterbirth/Hardmode, Isaac only: 1YHW AWGX
1st floor: blood od the martyr , synthotil, pentagram,
grown hormones, sacred heart, small rock, the halo, shielded tears in secret room in cathedral, capricorn, magic mushroom = 40+ DMG
WARNING!!! rebirth seed
take way to Sheol . . try to get devil rooms = HUGE DMG
EVVY HGEQ
tripple shot moms knife tech x tech 5 quad shot
MAKE SURE YOU REROLL almost every item room chest
normal mode afterbirth
tech x basement 1
tech 5 caves 1 after 2 rerolls
inner eye caves 2
mom's knife boss rush
quad shot, make sure you pick up lemon mishap before rerolling it other wise no quad shot
Sorry, I left out the item you get at the end of one of the bossrooms is iner
eye