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Play with Judas
NGBPKEC4
Magic Mush,Growth Hormones,(some dmg. Devil deals),stigma, double shot,
9E3D RDEW
-REQUIRES CREDIT CARD AND ALT. FLOORS FOR BEST POSSIBLE ITEM OUTCOMES-
Free Abaddon, Dark Bum and The Pact (I think...) because of Credit Card in Basement II.
In the starting room of Caves I or it's alternate floor, there is a challenge room. Touching the Cursed Chest furthest from the door will give you an Angel Room with Sacred Heart.
You find multiple damage ups throughout the run, as well as Cricket's Head in a Chest in the Womb, and Tough Love in the Boss Rush room. This run was hilariously overpowered, even though I wasn't really one-shotting anything. I was just obliterating everything in every room I entered.
Breath of Life does appear in an Angel Room on Necropolis I, which is a direct middle finger to a good run.
First Floor: Lil' Chub (treasure); Magic Mushroom (Boss)
Second Floor: Soy Milk (treasure - GET IT!); The Nail (Boss); Abaddon (Devil)
Third Floor: Polyphemus (+ Soy Milk = Speed+Power; treasure); Synthoil (Boss); Krampus' Head (Devil - DO NOT GET, still need Book of Belial)
Fourth Floor: Roid Rage (treasure); Meat (Boss); Contract From Below/Gimpy (choose one or the other! Devil)
Fifth Floor: D4 (Do not get; treasure); Mom's Heels (Boss); Goat's Head (Devil)
Sixth Floor: Taurus (treasure); (Mom); Lord of the Pit, Guppy's Collar(chest) (Devil); Cement Tears (Boss Rush); Mom's Wig (Rush Completion)
Seventh Floor: Pageant Boy (Boss); Guppy's Head (Devil)
I can't remember the rest, but it just gets better from there, even more so if you decide to ditch Soy Milk.
I made it through both layers of the womb and past the sheol without taking damage. I also killed the devil without doing a thing. You can actually play the game normally because of the OP items and beat the devil, but I was too lazy.
9NHK
Mom's Knife + Sacred Heart + other dmg ups = Something I like to call, The Holy Knife
Also if you have unlocked The Soul, you will find it on Cellar II, also by seeing that I mentioned Sacred Heart, dont take that Devil Deal on Cellar II, dont take too much red heart damage or else you'll miss out on Angel items.
Literally everything is one shot.
And a sidenote dont use Judas' Book of BELAIR
There might be more powerful seeds (that get boring as well) but this one will give you a lot of fun.