Most OP item combos

[fluffypancakes10]

What is the most OP item synergies you have run into thus far. It seems like a lot of potential for some awesome ones. Today I got monstro's lung, fire tears and then Polyphemus. I just ripped my way done to Sheol on my first womb run.

[The Grif Reaper]

i had Lacryphagy with Coloboma (a mod item) and a high tear rate... it's a never ending fireworks of tears. i one shotted Delirium

[nut]

BDK1W3SP - 20/20 with LOTS of damage up items!

[GiornoPIEC]

I would be suprised if you were able to get all these items but this is insta kill for even op bosses like ultra greed and mega satan
First of all use Magdalene if you cant use Isaac.
Brimstone: Host Hat: The Ludovigo Technique: Epic Fetus: Fruit Cake: 3 Dollar Bill: Holy Grail: Holy Light: Mutant Spider :GodHead : Monstro's Lung: And Lastly The Inner Eye.
If you cant get all these things.... just mod bro.

[LazyKirby]

forgotten+cursed eye+monstros lung+mutant spider+ipecac.

[Splorgoborgolo]

Tech zero and eye of belial. Shreds Hush within a minute.

[fakelolbit]

techX + 20/20 + conjoined + soy
helped me beat hush

[randomguy]

the most op combo is ipecac + pyromaniac with at least 2 heart containers and a non terrible fire rate. literal invincibility.

[Demabel]

C Section + nvm = compete run