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- The flies themselves are not always enough for more challenging rooms. Basically you'll want to get a spacebar item as fast as possible, either through the shop, minibosses, or other means. Myself, I got lucky, and managed to find guppy's head in a curse room.
- It's often a good idea to go in curse rooms as much as possible(at least before the womb), since you have flight, you'll only take damage on exiting. Keep in mind, besides the first floor, you might want to wait until after you kill the boss until going into a curse room, to better increase the chance of a devil room appearing.
- Devil rooms can really make this run, especially famaliars since, despite not being able to fire tears yourself, they still can. Two of the best devil items,( if you can find them) would be the brimstone-firing baby, and dark bum(provided you don't have many red hearts at least). Crampus' head would make an amazing spacebar item if you could get it as well. None of these are necessary, just probably among, if not the best one's for this challenge. Personally, I had sister maggy, ghost baby, and a brother bobby(though I got that from the fallen). All this said, I only barely beat mom's heart within an inch of life, so it's still no easy feat.
- Recap - master attacking with blue fly, get spacebar item asap, try for devil/curse room items, go with caution. Best of luck to you, hope this helps :)
The blue fly has more reach but does low damage. The red fly has short reach but does double damage. Use the red fly as often as possible.
I lucked out and got the brimstone baby which let me kill enemies at range (but not destroy fires or poops). This helped me kill mom's heart.
Got lucky to find a guardian angel in a godroom and also had a cube of meat. Lucky Pillrotation and HUZZAH ! It's done ! Also, the Bibel helped a little..... :P
So I'm guppy, lvl 2 meat boy, infested baby, the pact, and bob's head. I'm basically using my followers to deal damage, along with flies created from follower hits.
Only on 3rd floor, but not doing too bad so far
I am pleased to note I did beat it for a yearly update, though using demon baby, the easy out of the challenges.