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The Boss Rush room is theorized at present to only appear if you reach and defeat Mom in around 20 minutes (the timer icon between stages you've noticed).
Only go to this room if you have either enough Hearts/Spirithearts/Eternalhearts/"Shadowhearts" or port yourself outside with "Fool" after picking up one Item.
http://cloud-4.steampowered.com/ugc/537379928889470048/01D45785C2ED9EC1B93643F2A73D0E96D502F71C/
Yeah of course this i only for softcore.
But jumping in with just 1-2 "normal Heartcontainer" might be suicide as well.
Dmg+Shootspeed is necessary!
http://cloud-4.steampowered.com/ugc/36354470349546717/DE6A76CEC7D56CB323E5098C13C9239FFECAB571/