***SPOILERS*** Share the awesome stuff you find.

[Mathute]

Ok, let´s share whatever new stuff we discover while playing on these first few hours.

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First thing, I got into one of those rooms that take 2 keys to enter it literally switched my build. Now I have a really awesome familiar whose name I don't know.

Also, I'm (or my familiar, not sure yet) making enemies either flee or like me and they start attacking others (bear in mind you will still take damage from them).

And this is just my second run. Oh, the possibilities.

Oh, and the new secret rooms (the ones you go down a ladder) are kinda cool.

[1337Walrus]

Petrified Poop makes every pile of Poop you destroy have an item inside. Immensely useful for Basement and Caves, but ditch it Depths on.

[Darkunov]

I'm gonna just copy paste this here from another thread (it is one of my own runs though) :

I got an item early on that gave me "short range mega tears", which more precisely starts off as Mega and becomes smaller and weaker as it travels.

And then I got a new item, I forgot the name but it let me control my tear. So I had a permanent mega tear just hovering around owning everything. If that wasn'T enough, I had a rotten and ghost baby to take care of stragglers that would get close.

/endquote

I'm pretty sure the infamy actually blocks damage received from the sides. Anyway, if you unlock Maggy you can get it free in the "tank" challenge, among other things.

[Ashley]

Here's a big one:

After beating Mom in Depths 2, a part of the wall exploded and left a pretty big gap that brought me to a very large room (2x2 I think). There were a bunch of items on pedestrals and I thought "This is awesome!", so I picked the first one and the rest immediately disappeared.

What followed was an incredibly long boss gauntlet featuring every boss in the game (with the exception of end bosses), two at a time. After killing them all, I was rewarded with Isaac's Head. I have never seen this room ever since, and I believe it will only appear if you're doing VERY well (got a few of the "not getting hit" achievements during that run).

[love]

Holy shield.

Was basically set for the whole game.

[-ERROR]

Monstro's lung, but that was spoiled before release.

Spider Infestation that turns slain enemies into friendly spiders that attack enemies.
Holy Shield that negates one attack per room.
Rotten Baby - a familiar that shoots mulligan-style flies

[-ERROR]

Oh, I also got "There's options" - I believe that allows you to chose one of the two pedestals after each boss fight, and an item which I don't know that automatically applies My Little Unicorn effect when you fight in a new room.

[MasterROBO360]

I've found a brimstone-shooting familiar (ridiculously powerful), a pearl item that gives you charge shots (shoot large bursts of tears) but has a chance to teleport you when you get hit, and, of course, for any who haven't encountered this, there are WALLMASTERS FROM OOT in the game. They fall down, and if they grab you, you are teleported back to the starting room of the floor. FML

[ca]

I had brimstone and got this zero-gravity tears item. It made it pretty annoying to use since I had to charge the brimstone, then it just leaves a brimstone circle in the air (still hurts enemies) for a second before firing. Eventually I had fun with it by trying to lead the enemies into it.

[Curious Duck]

http://steamcommunity.com/sharedfiles/filedetails/?id=337073101
Space bar item in which allows you to jump over gaps...

[Joshua Kurayami]

Lil brimstone. Sweet..

[Ahoge-dono]

I got a black magnet item. It magnetized my tear shots and forces things to draw towards you...

ALL THE THINGS. D:

[Averagedog]

I used a Joker Card right before MoM after beating her once in a previous run. I used said card and ended up in a room with a goat head demon thing. There was a ladder leading down, I took it and ended up in a place called the "Sheol" I barely survived and cleared all the rooms. ON the next floor, I entered a boss fight with these two black demon things. Upon killing them, I thought the game was glitching or my game got corrupted by evil spirits or something because afte rkilling the boss, What can only be described as a Black Satan appeared and promptly killed me with one hoof stomp followed by a "I'M FIRIN MAH LAZORS" attack. I was confused and decided I probably fell asleep and died to Mom in the Womb 2.....

[rifraw]

3Th Secret Room !11
i wont tell you much i found it just once and its in 2D :))) look below you...

[Mathute]

Goat Head - Apparently increases Devil Room spawn chance

[Яedly Яed.暗赤色@Tsundere-Tiddy]

Found a shield which always takes the first hit = got Mama's Boy with it on my first Maggie run LOL