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The Binding of Isaac.
also look up the tag "rogue-like". There you will find what you seek.
also risk of rain is a bit similar. random pickups and stuff.
check out video of gameplay for those :]
FTL and Spelunky are probably my favorites. Rogue Legacy and Risk of Rain are good. Paranautical Activity and SotS: The Pit are okay. I haven't really played much Nuclear Throne but from what I've played it's pretty fun.
It also has co-op (online), but it feels fundamentally flawed- When one person pulls ahead, they just stay ahead, and as the other player drops behind, they get less and less, dropping them farther, etc. But as single-player, it's a great one.
I'm irked at PA because of the devs and promises not fulfilled, but its still a pretty good game. Risk of rain just got an update, and its a dificult game also. never played NT or Spelunky, but I hear good things. Honestly I'd reccomend FTL. Its an amazing game and its just as dificult (if not more imo) than Isaac due to its RNG-ness. I love it as much as isaac though. These 2 games and the elder scrolls are my all time favs :D
I know it might not be much compaired to others but between BoI and FTL Ive sunk ~ 400 hours of my life into them. but yes, in terms of actual gameplay, I think you were closer to the point than I :)