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For a devil room example, if you have 2 red hearts (
Since Isaac (or any character) can survive without any red hearts as long as they have at least half a soul/black heart, you can probably take advantage of this by using the Strength card and taking deals until you have no red heart containers left. Since you no longer have any containers, leaving the room can't take any away. I haven't tested this, so it's partial conjecture on my part.
Unrelated to using the Strength card, but if you only have one red heart container left, you can take a 2-heart devil deal for the price of only the one heart container you have. Be sure to have some soul/black hearts though, or the deal will kill you. In the original BoI, I believe this was also possible, but would take away all your soul hearts, leaving you alive but with "0" HP, where one hit would kill you. Rebirth does not take away your soul/black hearts doing this.