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You're basically swapping dependency on heart containers for a slightly slower rate of getting hearts (with extra benefits like devil deals being more-worth taking and challenge rooms being easier to enter and dark bum can fly to gather hearts)
The only bad side is when you have a lot of red heart containers, as there is a 12 hearts cap in Rebirth and when you get trouble at low health (1.5 hearts better than only 1, so you will have to run to the hearts before he pick them up).