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To get Tainted Isaac's unlocks. And perhaps because of personal preferences, if played more.
T.Isaac's ability kinda like a D6 for every pedestal and if you actually get re-rolls (luck into a D6 or getting stuff like Perthro), it basically doubles their effectiveness.
The only other advantage Isaac has over his tainted counterpart is that he can re-roll the same pedestal multiple times out of the gate, which is especially strong if you get something like a battery-bum on a floor with pedestals in the secret room for a very high chance of breaking the game right there.