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- The Cathedral and Chest fights have alot of tear spam so if I am going up I want 1 of two things, good orbital protection or alot of durability; usually with pure soul hearts for the shield every hit.
- The Sheol and Dark Room fights require good manuverability to dodge explosions, stomps, dark leeches and blood gushes so I want a build with high speed or a good stun or invincibility frames. High HP runs can do well in Sheol but often the demon fights getting to the Lamb will wear you down fast.
- If youve got the d6 or lots of keys Chest can save a run from the item drops if you've got a good enough build or the skills to survive the tier 3-4 boss spawns.
- if your utterly dependant on soul hearts or want to try for a last ditch guppy going Sheol/Dark may be the only way to get Dark chests after womb (excluding special rooms)
- If you dont have a good build for either direction then sheol tends to be a little easier since square straffing can trivialise phase 3 of the satan fight. If you've unlocked the negative take the polaroid and head down so you dont have to face the tier 4 boss rooms just the tier 3 boss rooms of sheol.
This is all my opinion and you should learn to internalise your own strategies for dealing with the rogue nature of the game. Goodluck, moms knife builds are powerful but often very vulnerable.
I hope they add a little more incentive to visit the DR in Afterbirth.
So go for Dark Room
EDIT: well this post was made 15 hours ago so I think he made his mind
me dudes