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Marrow, Smelter, Mega Mush, and Death Certificate.
There is the Co-Op babies as well iirc. @_@
And the answer is no. Why would anyone play regular?
https://bindingofisaacrebirth.wiki.gg/wiki/Hard_mode
The game is going to take a long time to beat even if you only play on hard.
For new players I suppose so, but anyone with working hands and eyes could get through Hard Mode, get used to it decently quickly and it'll save so, so much time not having to do lots of completion marks twice.
If you need to "save time" playing a game you probably shouldn't be playing it. It's not a job.