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There are certain items that are cheap to make with the bag which will drop collectibles wherever you make it. Latch Key for keys, Matchbook for bombs, Dad's Lost Coin gives you a lucky penny, Battery Pack drops batteries. If there are lots of excess pennies around, you can pick up eight of them and make the Portable Slot which will destroy your current active item and create drops based on whatever room you're in. You can force rare eternal hearts and bone hearts to appear this way.
You can also very easily break the game with the bag. For instance, get Car Battery + Clear Rune + Jera. Then make a Battery Pack to spawn batteries, use Clear Rune, and you can now effectively use Jera infinitely, meaning you can get infinite amounts of whatever is on the current floor. Get to this point and you're on your way to making whatever kind of run you want to have.
And as nice as the Jera loop sounds, I'm more concerned about even getting a SINGLE item in a run, with purpose instead of just randomly grabbing things until something "maybe useful" pops up in the bag. I'll keep that in mind, though, if I ever make it that far!
Didn't they patch that like a year ago or somethin-
1: Make sure to do all your crafting after you complete a floor, so you can maximize your pick ups
2: Each pool has a type of pickup corresponding to it. Bone Hearts typically make Secret Room items. Black Hearts go with Devil Room Items. Eternal Hearts go with Angel Room Items. Obviously the other pick ups matter but this is generally where the pools lie. So prioritize these kinds of pick ups if possible
3: The higher tier pick ups, the better. Soul/Black Hearts, Eternal Hearts, Keys, Bombs, Special coins like Nickels, Dimes, Lucky Pennies, etc. Avoid basic pennies if possible.
4: Don't be afraid to settle with what you got. If you got a decent stat up like an Odd Fat Mushroom or Synthoil, take it. You still gotta have an ok build to go through the run in order to get the rig items like Car Battery, Birthright, and your typical god tier items like Sacred Heart and Brimstone
TL:DR: Craft Late, Craft Smart, Craft Often
The most boring, too. I avoid playing him so much, that I forget that he's even in the game half of the time. I've never had any luck with any of the calculators.
The spamming portable slot machines in secret rooms was heavily nerfed at some point, but is still one of the better ways to generate higher quality pickups (I believe. I haven't touched him since i got his marks.) Generic coins are basically worthless, so it's better to exchange them where you can, unless you need them for specific recipes.
Portable slot is one, like Fake PHD, Brimstone and so on.
For the loot it still works in secret room