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- Take the Polaroid and beat the Cathedral again to reach the floor beyond it.
- Beat Sheol 5 times to unlock the Negative, then take it and beat Sheol again (dark counterpart to the Polaroid).
- Kill Hush once to unlock another end floor for further runs.
- Kill Hush 3 times to unlock the Repentance path.
- Beat the Repentance path to unlock another end path.
you then get satan - darkroom (Lamb)
Isaac - Chest (???/blue)
Hush
(major thing you wanna do is do Greed/ultra greed modes for Lost's holy mantle protection as it applys to a key segment to MOTHER)
make sure to donate a ton of money to your shops to unlock angel statue key peices for mega satan fight as relying on sacrifice room's blood donation for the angel's keys is not viable for low hp charcters
ive killed hush atleast once so far (and by god the amount of health he has is insane)