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If you're having trouble with Eve that Isaac hasn't given you, that suggests your problem is almost entirely due to taking too much damage. Taking frequent damage encourages you to hold a bigger red heart buffer, which knocks you out of W. of Babylon state, and burns your temporary health faster than you can replace it, locking you out of devil deals.
If that's the case, there aren't a lot of tips that will solve your problem. The Binding of Isaac has a classical arcade difficulty curve. Only time will teach you enemy behaviors and shooting patterns so that you can avoid taking damage effectively.
No I'm not taking red heart damage. Does it count if I take soul heart damage?
I assure you that I have the D6. You can check my achievements on my profile. But the thing is, I always seem to get bad pickups as eve. I'm on a lazarus run right now (taking a break from eve) and I get all these damage up items whereas when I was eve, I rarely got those. Idk man, I just feel unlucky while playing eve.
Edit: Huh, topic didn't update.
To the best of my knowledge, you can't reroll any pedestals into key pieces, so you have to bomb the angel room statutes to spawn the bosses and get them to drop.
The bosses themselves aren't too bad. They telegraph their attacks clearly, and their movement isn't erratic/unpredictable.
The main thing to note is that you'll tend to be missing some common damage ups/tear modifiers you'd usually snag from devil deals.
Black Candle and Match Book are good as well because they're evil up and increase the odds of you getting Deals with the Devil and get away with those hearts allowing you to stay in the ♥♥♥♥♥ state. Guppy's Paw is awesome too
Good Luck!