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If all you're looking for is angel rooms and a mega satan run you should reset until you find a starter (which i guess you already do) and check curse rooms aswell for a chance to find a goat head.
Using the Credit Card to take a devil deal for free doesn't count as you trading your soul and blocking angel rooms, so if you have that on hand you can still get a decent devil item without screwing up your angel chances.
Donating 10 coins to the donation machine is unreliable, since they're very likely to just jam around 6.
A few other things boost your chances...
Holding the Rosary Bead trinket changes the Devil/Angel chance to 25/75, and always works, no coins necessary.
If you find a Devil Beggar somewhere on that floor, blowing them up will increase your chances to find an Angel Room very slightly.
If you happen to get an Angel Room naturally, blowing up the statue and getting Key Piece 1 or 2 naturally gives a very slight increase to your chances of getting angel over devil.
Even if you just donate 10 coins and blow up a devil beggar, that's still a 81% chance of getting an angel room over a devil room...
Best of luck! Just got a Mega Satan kill with Isaac myself after a LOT of runs.
Avoid red heart damage, which is a given as always.
Avoid Evil up items, which even means, with credit card, do NOT grab any sort of demonic item from devil deals, for they will drastically increase devil room chances in comparison to angel rooms, like the Pentagram and the Pact.
Yep, same here. I recommend this strategy.
This card works like dad's key, so you can reach mega satan. I recommend you to go in shops and, if you find sack man power up, to take it immediately asap. With that item, you have a very good chance of finding that card in sacks.
Moreover, if you have bombs along with sack man, just keep bombing your donation machine because there are huge chances pennies to be replaced with sacks.
As this also works with alt + F4 this might not be intended and should be fixed.
Otherwise it's the usual angel room deal, bombing devil beggars will increase chances of an angel room . Never take an item for health in a devil deal or it will lock you to it, avoid picking up items that gives evil up.
The best way to get angel rooms from my experience is holding a rosary bead. So if you find one of those or get one from a fortune teller or mom's box(which doubles effect of held trinkets) you should see at least one angel room before the end of depths. Apparently you only need one as currently when exitig to the bossroom the angel room door will stay open and spawn a new angel(pretty sure this is a bug though).