What's the worst item?

[RangedSpider]

Not counting trinkets cards pills or ruins.

Based off of how useless it is no matter with what synergy.

[ogeraisi]

Either Breath of Life or Isaac's Tears

[Icedfate]

I hate tiny planet, and my reflection and I recently picked up the new dunce cap item...never doing that again

[Franky M.]

Cursed Eye is easily the worst for me.

[Moonfang]

Breath of Life will always be the worst

[tehtoes]

Cursed Eye is miserable.

[Elmo3000]

Definitely Breath of Life. Any practical use it has, which is nearly none, is countered by how annoyingly hard it is to use.

Tiny Planet is pretty bad, but what it does with Brimstone is probably the single best synergy in the whole game, so you have to give it that. Breath of Life doesn't synergize well with anything.

[Agamemnon-Hellmapper]

Breath of Life. No question.

[Grubberdeck]

For some reason (and I know 99% of the community disagrees with me) Mom's Knife is a terible item for me. I just can't work with it

[Zimmm]

Cursed Eye, Skull

and Bob's Brain these items shouldn't exist

[Shadowpaw]

So... I don't see anyone mentioning soy milk. Is it better nowadays?

[ogeraisi]

Originally posted by Shadowpaw:

So... I don't see anyone mentioning soy milk. Is it better nowadays?

Soy milk is not terrible, it makes it harder but it can have fantastic synnergies, same with Cursed Eye and Bob's Brain, the topic says "Based off of how useless it is no matter with what synergy"

[Shadowpaw]

Originally posted by ogeraisi:

Soy milk is not terrible, it makes it harder but it can have fantastic synnergies, same with Cursed Eye and Bob's Brain, the topic says "Based off of how useless it is no matter with what synergy"

By that definition, only breath of life is utterly useless then, as it's the only item that doesn't have any synergy. Even Isaac's tears have some synergies that are better than not having any usable item at all.

But useless =/= worst though. My runs have been consistently ruined by Soy Milk and Cursed eye rather than by Breath of life.

[ogeraisi]

Originally posted by Shadowpaw:

Originally posted by ogeraisi:

Soy milk is not terrible, it makes it harder but it can have fantastic synnergies, same with Cursed Eye and Bob's Brain, the topic says "Based off of how useless it is no matter with what synergy"

By that definition, only breath of life is utterly useless then, as it's the only item that doesn't have any synergy. Even Isaac's tears have some synergies that are better than not having any usable item at all.

But useless =/= worst though. My runs have been consistently ruined by Soy Milk and Cursed eye rather than by Breath of life.

Agreed, Breath of Life is completely useless and can't ruin a run but then again even Polyphemous or Quad Shot could ruin a run if you have very low speed due to their massive tears down effect which could cause to getting destroyed by enemies rushing you down, with that said as items that make the runs more difficult than usual Soy Milk, Cursed Eye, Bob's Brain, and Guillotine are up there.

[CitizenofZozo]

My Reflection is an item I never pick up, unless I'm Azazel. And even then, there are better items.
I rarely pick up the 3 Dollar Bill because it usually messes me up more than helps.
I've stopped picking up Marked because it's really only helpful against stationary enemies
I don't pick up Taurus because I hate the way it messes with your speed.

But the most useless items in the game (for me)
Cursed Eye
Isaac's Tears
Breath of Life (I've tried and tried and I can't figure out how to make the bloody thing work)
The Bible
Kamikaze!
Head of Krampus
Dead Sea Scrolls

These are items that I never, or at least rarely, pick up because they just aren't helpful 99% of the time, and a few of them will mess up my run if I try using them. The one exception would be Kamikaze + Pyromaniac, but I've not had that combination ever pop up.

[Moucheron Quipet]

I'm surprised there is Head of Krampus / The Bible in your list. Those items can one-shot many bosses (well, the Bible can one-shot 2 of them but still). I'd definitely take both of them instead of a Butter Bean or many other active items.