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So, rely on luck.
Always one guy
Good luck!!!
Thank you! I will try
tammy's head and brimstone
Here some usefull tips:
Block and push enemies with your body, stay close to your heart, destroy any potential damage from fire and red poop, it's important to have lot of heart containers (so don't spend your soul to devil deals unless you're 100% sure that this item will help you), don't take dead cat unless you want the eternal suffering of failure, orbitals can still be very good because you can block more incoming tears with your body and also deal a lot of damage with orbitals since you can touch them with out taking damage
Stay close to my heart?
-enemies that chase/enemies that shoot
-fast, unpredictable enemies
-everything else
-kill bosses as fast as possible (they don't last much, the sword is very high-damagin)
Other tips:
-It's the guy what takes damage, not the heart, so forget about the heart and protect that guy.
-You can BLOCK projectiles with Isaac, don't forget about that. You can't block brimstone lasers tho.
-Stay close to the boy, if enemies are coming for him. If they're coming for isaac, get away from him.
-On this challenge, health upgrades are more important that damage/tear upgrades (you can't even shoot, and the sword has enough damage to kill everything fast)
You need some luck, too. Rooms with mom's hands, and red champion mom make this challenge quite hard/maybe even impossible.
Just keep trying, you'll do it eventually.
and always.. ALWAYS... keep the thing away from red poop. destroy all the fires.. all the red poop.. and run to the next room before it touches a spike..