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For example, restart Greed Mode, until the 1st floor shop has Blank Card, continue to farm money for it and farm cards in the later shops, until you get "2 of Diamonds".
Now find/reroll a shop with a battery while having at least 11 coins = infinite money and since the Greed Mode shops (or any other shop really) start drawing from other item pools, once theirs exhausted, you'll get Mega Blast eventually.
I probably picked up "Chaos", when i broke Greed Mode, when i started to get Devil Room items but since you'll always get that, it shouldn't matter.
Other than that though id say blank card, 2 of diamonds and picking up chaos, in greed mode shop, would be the best 'breaking' option
If you have a chance to break the game then do it, but don't prioritize it. Just keep playing normally should be enough.
To break greed mode:
Get infinite money with Blank Card + 2 of Diamonds + shop that sells batteries.
Get infinite reroll with Cracked Dice + Habit + Blank Card + a restorative card (The Sun, 2 of Hearts, or something else), keep hurting yourself with the fire in the devil room. Make sure you have enough heart containers though.
(Since there is no Goat Head to help force the door open you'll have to get everything before going in.)