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Did you trigger an Addicted pill in that room? Its effect is to change all damage into full heart damage for the current room.
Otherwise, champion monsters naturally deal a full heart of damage, and all floors beyond (and including) Womb1 change damage instances to full heart only.
Ok so, i was with Cain so i suppose there cant be a addicted pill, also i switched rooms alot and even a fly was doing double the damage (and i was playing in normal mode)
Oh btw i got so lucky that most of my items were the ones that you get an item on pickup, like the pink crown that spawn 7 coins