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PS: I'm playing without mods, I already know that affects the progress until you beat Mom once.
Check here how to enable the debug console, just put it at 0 instead of 1 to disable it:
https://bindingofisaacrebirth.fandom.com/wiki/Debug_Console
You can enable them again and still unlock things once you've unlocked the Womb (first Mom kill, in-game secret number 4). Before that point, they prevent all progress. This isn't a bug.
List of things that prevent all kind of progress:
- Seeds (except a few special ones)
- Challenges (except for their reward obviously).
- Daily Runs.
- Reruns and Victory Laps (except for a few specific unlocks).
- Any active mod from the mod menu before Mom is killed once on that save (no matter what they do, other saves are irrelevant).
- Enabling the console before Mom is killed once on that save (even if you don't use it).
- Paranoid antivirus programs (or missing rights) preventing the game from creating/editing its save file.
Sure you edited the one at the correct path? (Refer to the file path mentioned on the wiki. Don't trust shortcuts, go there manually if you have to.)
The only strange thing I've noticed is that I have several different .data files in the folder, still no progress is shown.