Any tips for Brains challenge?

[Nero]

As the title says, this challenge is whats keeping me from 30/30 regarding challenges.

[Hans]

I got empty vessel and book of shadows to complete it, but you really need a lot of luck.

[Nero]

Im gonna need a lot, i only got to Womb 2 before getting mobbed by lasers.

[burn1none]

Use shops to your advantage namely blue or red candle and of course you can pray you'll get lucky with chaos. It's actually pretty easy to get a lot of money from pots in this challenge because thunder thighs. I managed to get a blank card on my winning run with a Jera rune I was lucky enough to find a challenge room that I could double all the chests on so I found the one that had an item and filled the room up and got so op I almost froze the game I'm pretty sure. I was able to get even more lucky after I found a dice room that let me redo the exact same floor so I figured why not and did it again. Cleared every room in about half a second after that and eventually got kamikaze and was able to clear rooms almost instantly even final two bosses. I got super lucky to be sure though.

[Nero]

Thank you for the tip, i'll make sure to try it :)

[JellyPuff]

I've beaten the challenge entirely on the back of Lil' Brimstone. (And the brains, of course.)
So, any top-tier familiar should be able to carry you. The brains alone are fine for killing bosses, but not optimal for completing rooms, so Incubus and Succubus work exceptionally as well.

And as already mentioned: Shops. BFFS should be also an instant take. (one brain will then deal ~130 DMG, but the larger brains can be riskier)

Remember, you start with Thunder Thighs, so smash every rock to look for crawlspaces. Libraries should also be checked out whenever possible, for Satanic Bible/Book of Revelations, to set you up defensively.

[Deggo]

I've done it with BFF and Satanic bible - a consistent way to generate health really helps a lot.

[SonicDen220]

Ursprünglich geschrieben von Gnebbers:

I've done it with BFF and Satanic bible - a consistent way to generate health really helps a lot.

Wow, me too. Except I also had Rotten Baby.

[JellyPuff]

Ursprünglich geschrieben von SonicDen220:

Ursprünglich geschrieben von Gnebbers:

I've done it with BFF and Satanic bible - a consistent way to generate health really helps a lot.

Wow, me too. Except I also had Rotten Baby.

BFFS doesn't affect the Rotten Baby, sadly. Well, he does get bigger.
Hivemind does, tho.

Imagine BFFS would work with him and you get Hivemind.

[SonicDen220]

Ursprünglich geschrieben von Jellypuff:

BFFS doesn't affect the Rotten Baby, sadly. Well, he does get bigger.
Hivemind does, tho.

Imagine BFFS would work with him and you get Hivemind.

I know. It'd be wonderful if that worked. It's a shame I couldn't get Hive Mind on the first floor because I didn't have enough money.
And now imagine if they stacked. Quadruple damage from a single fly.

[Nero]

Wow, thanks for all the tips, im sure i'll be able to beat it now :)

[Renti1230]

Super item on this challange is Gnawed Leaf on Crawl Space

[shadowkno3]

I was able to beat the Brains challenge by getting magic fingers from the shop and then finding the lucky rock trinket. I was able to keep almost max coins and pretty muck solely rely on magic fingers to clear the rooms. Because hearts are so hard to come by I was hunting for angel rooms and lucky found one with sacred heart in it which dramatically scale up the damage of magic fingers to the point that it only took about 20 coins to kill Isaac. It took me a long time to complete this challenge and a lot of luck. Hopefully this helps you out with another strategy of how to beat this challenge.

[Der Löwe]

I did it with Chaos plus Pyromaniac from a gold chest, just pray you'll find Chaos in a shop

[AutumnLeaf]

If you find an Emperor card, do NOT use it right away. Save it for the Chest. You absolutely don't want to go through a boss gauntlet with Bob's Brain as your main source of damage.

[Nero]

This just shows how helpful the Isaac community is, thank you for the multiple strategies :D