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Unless you manage to re-roll items inside the room until you get another item from a chest or re-roll the entire floor with the 5-dice-room or Forget me not and reach again the boss rush before the mark of 20 min.
The timer has not yet reached the 20 minute mark
AND
You have the ability to create a pedestal item in the boss rush room such as by using a Judgment Card and feeding the beggar until he creates one.
I ended up just pausing before I got the 'this thing killed me' screen, exiting the game, and reloading the save to attempt (and finally beat) Boss Rush as The Lost.
I wouldn't have done it if I didn't have extra lives via Dead Cat, but it was too much to ask that one of two 'essential' items for The Lost didn't work on Boss Rush.
And my setup was pretty ♥♥♥♥♥♥ good as well.
Synthol, Roid Rage, Death's Touch, a couple other speed/damage ups, three Pretty Flies, Lump of Coal, Odd Mushroom (thin), Hive Mind, and the Guppy Transformation.