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Also, the damage formula has a square root in it, so you can get diminishing returns by getting lots of damage ups, though multipliers are still always valuable, and the bonus from ipecac is outside the square root.
Oh, I forgot to mention that the seed also has Mutant Spider at some point before Mom's Heart. The bosses that survive a hit surely won't survive four.
having an OP run like that every now and then sure feels amazing
https://www.youtube.com/watch?v=JujGO1PRPM8