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I mean the most powerful one I have had the pleasure to find was Filigree Feather and The Stairway and if you get that early...... just wow.
But I am looking for the synergies that have "transformational" qualities so to speak. Not to be confused with transformations, if that makes sense. Like as I said the two items I previously mentioned.
Filigree Feather is also amazing, if you have some way to generate HP or heal, since then you can play Sacrifice Rooms for 2 Angel Items. If you look at the trinket's wiki, you can also find out, how unexpectedly absurd things get, if combined with Meat Cleaver.