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C:\Users\Owner/Documents/My Games/Binding of Isaac Repentance/
find the file labeled options.ini inside this folder, change the line that says "fullscreen=1" to "fullscreen=0"
I usually have to boot the game up in windowed mode, and it starts up with the window stating it is "not responding" for less than a minute.
If just doing the above does not help, I would recommend backing up a copy of your "options.ini" file to your desktop, then you can change out the options to the ones listed below. I'm not saying this will work for everyone, and I doubt this will help steamDeck users, but it might help if you just have a slightly out of date PC.
[Options]
Language=0
MusicVolume=0.4000
MusicEnabled=1
SFXVolume=0.9000
MapOpacity=0.3000
Fullscreen=0
Filter=0
Exposure=1.0000
Gamma=1.1500
ControllerHotplug=1
PopUps=1
CameraStyle=1
ShowRecentItems=2
HudOffset=0.1000
TryImportSave=0
FoundHUD=1
EnableMods=0
RumbleEnabled=1
ChargeBars=1
BulletVisibility=1
TouchMode=1
AimLock=1
EnableDebugConsole=0
MaxScale=99
MaxRenderScale=2
VSync=1
PauseOnFocusLost=1
SteamCloud=1
MouseControl=0
BossHpOnBottom=1
AnnouncerVoiceMode=0
ConsoleFont=0
FadedConsoleDisplay=0
SaveCommandHistory=1
WindowWidth=1266
WindowHeight=706
WindowPosX=190
WindowPosY=213