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Sigil over anything.
But in general, i'd say Cracked Dice. Even post-nerf, Cracked Dice gamebreaks are still the easiest to pull off, since all you need is some kind of pick-up generator, like a Blood Donation Machine or the inevitable IV-Bag, which conveniently can also trigger the trinket. Bonus points, if you get Mom's Key or Piggy Bank from the Shop. Played right, it's almost like having The Habit+D6+D20, but combined into trinket.
-cracked crown is the goat.
-wooden cross / Sigil of Baphomet is good on every character (biased do too trauma of T'lost)
-Crystal key. more rooms more loot
-nose goblin / curve horn / cancer and brain worm are all equally good
-perfection. +10 luck... it realy good. but sometime that not what you need
-blue key is a sleeper hit and it very useful early in a run
Should literally have been an item