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Focus on doing familiar damage when you do runs with other characters.
It feels really awkward to begin with, but you will get more comfortable with time.
She starts with it, but you have to unlock it by beating Greed Mode with her to make it possible for it to show up in the game for anyone else.
It's also worth pointing out that you should never underestimate her items. Box of Friends is really really good, and Cambion Conception can give you access to some really good familiars if you're taking a lot of damage. Dark Bum is in it, for instance, as well as Lil Brimstone, I think you can even get a second incubus out of it if you're lucky. You can also get completely screwed and end up with the Leech, but that's just how it works.