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Actually, to get the D6 you need to use Blue Baby and beat Isaac as him.
A requirement for opening Angel rooms is refusing to take offers from the Devil room on the run. If you open a devil room on any floor before Mom's Heart's floor, then that should gaurantee that the door that opens after her fight WON'T be an angel room, right? Also, if you defeat mom's heart 11 times, it will unlock an alternative version that will, upon defeat, always give you the option of sheol and the cathedral, so if you don't want access to be left up to chance, take that course (you're gonna have to eventually anyway).