Help with greedier

[randomguy]

Title kinda says it all. Any greedier enjoyers know how to play the gamemode properly? Or are you supposed to just hold R until basement dmg up?

[JellyPuff]

In Repentance, pressing the button no longer affects the total amount of coins spawned, so as long as you have the HP for it, you can stop the timer, without any downsides. You can then buy something from the shop in-between waves, to help you with later waves or the bosses.
Except for The Lost and T.Forgotten, which get a -1 coin penalty for the next wave (can be negated with a glitch, but it's more hassle than it's worth).

For some tainted characters or a low DPS Eden start, there really is no reason not to hold R, though, unless you want to streak.
That being said, it's also incredibly easy to break Greed Mode. Like so easy, you only need a single D20 or Cracked Dice trinket to get all the items and pickups, you could ever want. Leave all the spawned coins on the floor, re-roll them, open all chests, pick up enough coins to buy a battery (D20 only) and re-roll again. Rinse and repeat until the room is full of pickups and items from golden chests.
And there are still other ways, to break it too, like Blank Card+2 of Diamonds/Card Against Humanity or Clear Rune+Jera/Soul of the Keeper, especially with Car Battery and/or The Habit.

[ploeppsel605]

An advice that works for every greedier run is to primarily take items in sale. Save up coins to spend them all in one go on those items. Only pick up very strong items for 15 coins (in general or for a specific combo like car battery for lillith. This way you get twice the amount off items you would get otherwise

[kone]

Go Angels. Angel item pool in Greed Mode is very strong. Devil Rooms are very risky with item pools, room layouts while you also spend health. Devil Rooms are instead better for characters that have/want no health.

Don't be stingy when you should restock until you find items on sale. Preferably items from the Treasure or Shop item pool.

[Saph]

I use a method where you restart until you get Larry .Jr on the last wave. Stand in a corner or fly above a rock and he can't hit you. Every 30 or so seconds, quit and reload to turn all the "Larry poops" into normal ones that have a decent chance to drop consumables. Get Petrified Poop, repeat ad infinitum and you can buy everything from the shop pool over time to cheese this stupid game mode into the dirt.