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Why not go through the regular game a few times first so you know what you're doing?
It'd be a good idea to actually know how to fight the end boss of these challenges before you actually try them.
Challenges are what they're called, challenges. Some might look easier at first, but they need you to go pretty far in the game without any treasure room (the ones with golden doors giving you items).
Beat Mom (the 6th boss) at least once. It is considered here as "you completed the tutorial". Then, kill the 8th boss a few times. You'll be ready for the easier challenges at that point in my opinion.
For now, learn how to play the game. Challenges are for later. ;-)
You can see the final boss of each challenge as a symbol below your heart containers, if you didn't know that already.
Death's Touch is a passive tear effect that gives penetrative shots AND a damage up, and it shows up in Devil Deals (as a 2-heart deal), and Treasure Rooms.
Seed: 9BPW LJXW
Died to Gurdy on the third floor. Cripes.