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Go to C:\Users\"NAME"\Documents\my games\Binding of Isaac repentance
Then open options.ini with the editor and change "EnableMods=1" to "EnableMods=0"
This should deactivate your mods in isaac.
Then start the game and reactivate your mods and try them out.
If they crash the game, leave them deavtivated.
I appreciate the input and I tried it, but that didn't seem to work as I still can't launch the game. I really appreciate the help though!
This game was developed before windows 11 came out so compatibility mode might actually help.
Hey idk if you figured it out but when I had the issue I just deleted the whole modded versions file in my games and it worked