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And here’s the few recipes that are always the same:
https://www.reddit.com/r/bindingofisaac/comments/qtcqey/tainted_cain_fixed_recipe_list/
Fanny Pack + Habit (very common) + Old bandage (also common) - this way you can abuse Tainted Cain.
Then take 8 hearts to create active healer. And damage yourself to get pickups.
Then using the list above you can create a lot of keys (Latch Key to increase luck), Soul Locket for stats, Sacred Heart and even Death Certificate.
So yeah. Threat Tainted Cain like any other character, and be happy you get items through every floor and rooms, and that you can also skip bad items, and try a different combo.
You will very much understand this when you're starting to do Boss Rush / Hush runs, because you won't really have time to think that much...you just have to craft, craft, craft!