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Focus on dodging. Not getting hit is better than hurting other things.
Learn monsters' patterns and behaviour, and therefore how to manipulate them.
I think that it's particularly helpful to search up what items do or even install an item description mod since it aids significantly in the confusion that comes with not having the prior knowledge that is built upon experience. I'd recommend this mod (don't worry it's not cheating it just provides information that's all) however it's important to note that if you haven't finished a run you may not be able to get it to work since mods require you to beat mom if you want to unlock things with them on.
https://steamcommunity.com/sharedfiles/filedetails/?id=836319872
Now how I got into isaac was through watching youtube videos. I've found that even just watching other people play can prove very useful for learning how things work especially in regards to fighting enemies or bosses. I would steer clear of watching modded content though since it can be a lot different than repentance. It's probably best if you watch unedited runs of someone playing on a new save file. That way the game is near identical to what you're playing.
If you're just not interested in watching youtube though then here are probably the most important things I've learned:
- As a newer player you tend to focus on health more than damage. You'll find the greatest success in runs where you get a balance between health, damage, and tear modifiers
- Some runs you just get unlucky, don't blame yourself for losing all the time. You've gotta give credit where credit is due though, a win is a win even if it's an easier run
- Trust me, it's a lot easier to play when you're level headed. When you get tilted from losing again and again you just start to make stupid mistakes. Try taking a break every once in a while if you start to get frustrated
- Don't be afraid to take as long as you like to finish a floor. If you're looking to win it's worth your time to utilize all of the resources available to you. Take every item from every item room, buy things from shops if you need them, carry pills and cards with you even if you don't need them at the moment. You might not want to take damage from spike and curse rooms though
- More about cards and pills, cards always have the same effects which are summarized as a note underneath their name when picking them up. They're best utilized when you know what they do before you use them, so check what it's effects are in case you don't know. Pills on the other hand are randomized at the start of each run but each color will always have the same effect for the rest of that run. Generally speaking though pills are much more risky then cards since they can provide instantaneous advantages but can also give.. disadvantages. You may want to avoid using pills due to how random they can be
- Tinted rocks are special kinds of rocks that give you rewards when you blow them up like soul hearts, chests and more bombs. They are slightly different in color as the rest of the rocks and have an X mark on them. Search them up
- Secret rooms are special rooms that can be found when bombing certain walls with specific conditions. They can have all kinds of different stuff in them. Search them up also
- Turning on the map, found HUD, and bullet visibility can help you keep track of important stuff that's going on in the game. If it's in the settings then take advantage of it as you please
But most of all, you will improve the more that you play, no matter how hopeless it may seem at the start it's just like learning an instrument. You will learn things as you go and it's up to you to pay attention to patterns and key pieces of knowledge that make the game easier. You will see success as long as you put forth the effort. It may be tonight that you get your first win, it may be next week, but when it finally happens it's those moments of relief that make this game worthwhile. Good luck, friend!!!
The problem is that the durable way to learn those things is, really, by encountering them over and over again, which means just grinding along failing over and over until one day you don't. That means just playing a lot of Isaac, which I certainly encourage you to do. Some of the things you just have to get a feel for, rather than being able to learn ahead of time.
Then there are the YASD types of deaths that players of almost any skill can bumble into: walking into a curse room without enough health to get back out again, or sacrificing all your health buffer trying to win an item from devil bums and getting killed before you can build it back up, or picking up an item that makes your shots explosive when you aren't comfortable with aiming, or getting the Curse of the Tower or Bob's Brain when you're not prepared for them, etc. etc.
I imagine it's easy for a new player to look at all the stuff there is to learn and get overwhelmed. It's probably best to just play and learn things as you go. It might not hurt to look up exactly what a given trinket, item, or card (or whatever) does right before (or after) you get it, if you want to save yourself some time. Not knowing exactly what some unfamiliar thing does is kind of the quintessential Isaac learning experience, but if you aren't in the mindset for dealing with that kind of obscurity it can get frustrating pretty quick. That's all up to you and how comfortable you are with maybe not knowing exactly why something is happening. I've played quite a bit of Isaac and I still have those "hold on, what just exploded on me" moments.
-You'll learn the patterns the more common enemies use and how to avoid their attacks
-You'll learn the game's quirks and design language and begin to figure out where hidden rooms and other secrets lie, as well as which items to avoid and which ones to pick up.
-You'll unlock new items and characters for completing achievements, which in turn can help you unlock more things.
These three things will help you build momentum over your first few hours, and soon enough you'll be hot on your way to beating Mom and unlocking new final chapters. You have to stick with it to get up to that point though.
While also not fully in the spirit of the game (and obviously not helpful if you also play Isaac on consoles), if you have the DLC, there are a decent handful of assist and quality-of-life mods on the Steam workshop that can make the game easier; things like external item descriptions, reworks on the boss armor system and item rebalances, and new items and characters.