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If you will get health regen item, you're in good place. Stopwatch/broken modem also make it more managable.
If you have a lot of spare bombs, they can put two for one and kill bosses easier.
Alt floors for double items, I guess. In practice, it's not that much since one of them is random, it's harder to plan who gets it, and it's only one extra item per floor. Angel Rooms do often give you multiple choices too however.
Dont forget, when there is a choice pedestal, you can take both items at the same time, one for each char.
Good general advice so far though about Jacob and Esau though, thanks guys. I dumped everything on Esau and beat Hush this same run.
The Ol' Reliable I used for some AB+ ♥♥♥♥♥♥♥♥ like Ultra Greedier, Delirium or Keeper was Tarot Cloth + Algiz, which on runs with at least decent damage was enough to get you a free boss kill. Tarot Cloth used to work with runes, in this case giving you 60 seconds of invincibility, and was somewhat common being in the Shop and the relatively small Curse room pool. Alternatively Blank Card worked too, or grabbing two Algiz runes with Starter Deck.
If you had enough damage, even just an Algiz would do fine, with the exception of maybe Hush and his armor. For him however, I'm drowsy was almost a win because it butchered the range of his bullet hell.
This has since been nerfed in many ways, but Book of Shadows + 4.5 Volt exists, which is debatably even more busted and easier to come by (a library item, which is a pool with 15 items, often multiple choice, and which you can reset for floor 1, and a shop/charge beggar item, with around 1/8 chance in the latter)
This only really works for bosses however and you can still die on the way there. In fact, for the two new final bosses in Repentance, I think the lead-ups to the bosses are harder than the bosses themselves.
https://youtu.be/73XIOswDgzo
my fight using J&E on Deli, took forever.
Hmm, that's not the case for me. I managed to kill Delirium pretty easily with broken stopwatch and its slowdown effect.