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Something like Venus, Luna, Uranus and Pluto can really benefit a run.
However at worst you have a chance to get that annoying item Jupiter.
Except when theres crap in it like one of the ♥♥♥♥♥♥♥ beans, or the poop.
(The first doesn’t require a key, and I’d like some kind of upgrade at the beginning.)
Venus is ridiculous, basically a stronger 2spooky4me.
Uranus is one of the most busted items period.
Saturnus is great for additional damage and also gives protection from enemy tears like ring of light.
Neptunus can make you vomit an absurd amount of dps by salvas.
Pluto is great to avoid projectiles, and is a tears up.
Jupiter gives 2 hearts and has good crowd control. It could be considered the weakest due to the fluctuating speed.
Terra is an amazing damage up+utility.
Mars allows a lot of abuse with invincibility frames(curse rooms, escape, etc) and can carry you even with base damage.
Sol is the ultimate min maxing item, also allowing to speedrun to the boss, and the void is a joke.
Mercurius transforms the floors into walks in the park and you just go where you want skipping annoying rooms.
Every single one of them is a level above general items you can find in item rooms, how would you not want them.
Taking the mausoleum route after the mines, skipping the first item room, you have 6 times 21% chance, which is vastly more consistent than 4-5 times.
1 - Terra - One of the best, does insane damage and breaks stuff.
2 - Luna - Meh, the tears are okay, if you have a few bombs you could make good use of it. + If you're lucky, you can get additional items from the secret room pool.
3 - Jupiter - One of the worst. Gas deals good damage, but you'd rather deal damage with your normal tears.
4 - Saturn - Ring of tears is decent, if you have penetrating shots it's super powerful.
5 - Venus - Super fun! You can just walk near stuff and they fight among themselves, also the HP UP is definetly good given how Red Health is valuable now.
6 - Uranus - Insanely powerful, the freezing tears prevent champions from bursting and exploding, also enemies that split or regen are instantly frozen upon death. Let's not forget you can also push the statues for aditional damage.
7 - Pluto - Really good aswell! Specially with characters like the Lost, helps a lot at dodging things and tears up are great.
8 - Mars - Kinda bittersweet. It's good for getting inside of curse rooms for free and if you're playing a character with heavy contact build, it's insanely powerful.
9 - Mercurius - The one I least used, it's for speedrunning, that's it.
10 - Neptune - Can be good if you don't have special tears, as they simply overwrite netune's "floodgate" effect.
11 - Sol - It has an insanely good effect but it comes with the risk of having to beat the boss first.