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If that's not what you meant, please clarify.
Simply play the game, you will unlock most of the stuff naturally, then you can look up the rest. There is no "optimal route".
the game is random you can choose what you want to unlock and then read what it needs(character and things you have to do) and then keep trying till you get it
also what i think youre asking is seeds so you get what you want in the first try
seeds disable achievements
Afterwards, beat Mom's Heart numerous times and then beat Satan and Isaac 5 times on Normal mode to get the Polaroid and Negative. Also beat Hush 3 times on Normal mode to unlock the door to the alt floors. Afterwards, you can start playing on Hard mode for everything else.
Some things I suggest you unlock as soon as possible are: beat Isaac with Blue Baby(gives Isaac his D6), beat Satan as Isaac(gives you Mom's Knife) and Eye of Belial(beat Greedier mode with Judas, though you'll have to play Greed mode and donate 500 coins) Always prioritize leaving money for the donation machine in the regular game, as you can probably live without that 15 cent Ladder. That's just for the ''beginning'' part, though.
Later on you should also do challenges like Family Man, XXXXXL, Cursed and Blue Bomber. Doing Isaac's Awakening and Seeing Double challenge is also not a bad idea as they both have solid unlocks.
A typical strategy to do that is unlock azazel as son as possible , you just have to take 3 devil deals in one run.
After that you can use azael to quickly beat mom and the heart repeatedly . Exist a glitch when you end a run that allow you to continue the run at the start of the floor again, Doing that I unlock all the floors in only a few runs.
Exist a lot of strategy like that but I want found a guide for all the achievements. and for follow the strategy of the streamers I have to see dozens of hours of videos and i dont want a do that.
He starts strong and surpasses the lowered Brimstone and missing flight within the run, as the difference in positioning is a huge benefit towards the fightstyle of Azazel.
As a different Comment.
It depends on your skill as well.
You can go for Hard, especially, if it's about completion marks right away, if you feel and avoidence for doubledoing stuff, and switching from Hard to Normal, if there's no aquireable achievement/Unlock or you prefer to put the Unlock on a Subsequent run which is needed for the overall completion, but since subsequent runs are needed it might be a subjective missperception.
Unlock Halo early by Killing Mom with a Bible if you already started.
Early Unlock of the whole game is a good approach and then going for the "Retry" on Hard of it.
Another use for Maggie is reset the first floor until you have a sacrifice room , if you try a few times you can start a run with two angel items and a lot souls hearts . Can be a really strong start and you can try to do the bosh rush or hush.
The most fun part of the game for my is learn how to make the better use of the characters and items. That's why i was asking for a guide with good ideas to obtain all the achivements in a optimal way.
Bloodbag is a great upgrade that can happen. And with the chance of Habit and doublecharge through the coin access in stores does offer an early late protection, a lucky waver and the game might be yours on 2 redheartcontainers....