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So anything that sizes the character down is a hindrence.
Acid Baby wasn't mentioned, it drops pills every few rooms.(If I got the name right.)
Magic Mushroom will up your size as well.(The one with all stats up.)
The tables with the mirror which changes the appearences of your character have moved in room, though I would try to see if you find some of them, they are in the rooms with beds now I read, and in Front of Hush there should still be one, bomb those.
Do avoid Deck of Cards.
Check unknown pills with Placebo if possible.
Double Active is usefull when playing Placebo.
Strength does only count for the room, that is right and it's not possible to stack the size, through multiple Strength cards.
(the wiki also says that multiple strength do count)
If it states that, then it's most likely like that.....
Still the effect only lasts for the room, so you should be sure, that you use it as last tool to achieve the size.