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Best strategy for Tainted Laz is to try and get both sides with a semi-decent run, focus most of the early game dmg and tears ups on Alive Laz cause dead Laz has much better stats.
If you get Star of Bethlehem on one of them it can carry your run really hard and you can just give every item to the other character.
Honestly best way to win is maximize every floor as much as you possibly can. Most of my runs where I won were almost an hour long because you just have to take literally every single opportunity you can get to win as this character.
Hardest achievements for me by far were Boss Rush and Hush because you have to go fast and you usually end up really underpowered when you get there. I got Boss Rush by getting lucky with Gnawed Leaf and potato peeler for tier 4 meatboy on Alive Laz and then IBS on Dead Laz which just hard carried me in boss rush with the Hallowed Creeps and constant bombs. Most of the other achievements weren't that bad if you just take your time and pray for good items.
Always go angel deals also and make sure to have Flip ready every time you enter the boss room. Try and keep some uncleared rooms around when fighting the boss so you can use them to Flip if you burn the charges but need an item on the other character.
Greedier with Tainted Lazarus was one of the most frustrating things I've ever done in my life. Every run I was just too weak to kill enemies quick enough so I would either have to get swarmed by a bunch of enemies or keep pressing the button and dealing damage to myself. I eventually ran out of patience and proceeded to take the easy way out with the classic Tainted Cain clicker strategy, but I happened to change to Tainted Forgotten TWO RUNS IN A ROW, softlocking the game, so I gave up on that. Thankfully after that I was lucky enough to find mega mush on the first floor so I just stomped on everything with Alive Laz while giving all the items to Dead Laz.