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Alternatively, if you have a lot of health to spare, offer a bunch of it on the spikes of a single sacrifice room (all on the same floor).
Either get an Angel room after killing the Heart to go to the Cathedral or kill the Heart 11 times to unlock a permanent access to it.
Then, beat the Cathedral 5 times to unlock the Polaroid, it'll be dropped by Mom on later runs.
Then, take that item, and beat that floor again. It'll send you to the Chest.
Note that there's a mirrored path on the dark side. It uses the same logic and unlock method, just replace Angel rooms with Devil rooms, the Cathedral with Sheol, the Polaroid with the Negative, and the Chest with the Dark Room.
Still, don't rush things, take it easy, just play more and you'll get there eventually.