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Do not use any mod before the first Mom kill on that save (= unlocking the Womb). They prevent unlocks before that point, but nothing afterwards.
I also thought of that idea as ridiculous but in practice that's just what's happening. After some research I learned that thing about not using anything before beating Mom once.
I've tried deleting the saves in-game, the save files in the appropriate folder, reinstalling the game, no dice.
List of things that prevent all kind of progress:
- Seeds (except a few special ones)
- Challenges (except for their reward obviously).
- Daily Runs.
- Reruns and Victory Laps (except for a few specific unlocks).
- Any active mod from the mod menu before Mom is killed once on that save (no matter what they do, other saves are irrelevant).
- Paranoid antivirus programs (or missing rights) preventing the game from creating/editing its save file.
If you are in any of those situations (except the last one since it isn't in-game), the symbol appears. Leaving those situations (meaning: starting a regular, random run with no mod at all if before the Womb unlock) will remove the symbol.
If you're before unlocking the Womb on that save (secret number 4) and have any mod enabled in the mod menu, disable all of them for now. Doesn't matter what they do.