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Nope.
There's a total of six more bosses after Mom's Heart.
Satan, The Lamb, Isaac, ???, Mega Satan, and Hush. There will likely be at least one more boss once Afterbirth+ comes out too.
The difficulty is fine.
They really seem to be intended as the kind of boss that would be hard for new players but reasonable for experienced players.
I think this is what they went for, for sure. But I think it failed on the latter half of that idea because experienced players will almost always be completely overpowered if they get that far. The problem really is with the number of powerful items and synergies, not the enemies or bosses.