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These items are too powerful together and are difficult to get with others, and plus having good items is never a bad thing, just too many of them is.
The only possible pools for it to spawn are: Item Room, Boss Room and mushrooms
Also, since you seem to love anecdotal evidence: I see magic mushroom pretty rarely. So there you have it. All is fine.
BTW ^ Bloat's not hard if you just stay in the back of it. It can only fire brimstone at you from the sides and in front.
"Good item"? More like overpowered. The amount of good items today is about 80%. In fact there so many overpowered and good items that items that used to be considered as good are now bellow average or trash. The game never has never been so easy to break to build. The reroll machine in the shop is one great example to greatly manipulate,cheese and break the game. The binding of isaac got so casualized that I find tag "hard" in store page is an insult and fake.
Hard bosses like bloat? Hello? The game supposed to get harder and challenging as you progress further. Second difficulty bosses mean ♥♥♥♥♥♥♥♥ if you're overpowered and can kill it in 1-5sec. Only bosses like Hush that has damage resistance are ballanced to have a chance to fight back.
If someone who really needs a buff it would be all bosses and enemies - they should get damage resistance. So you can still build your crazy overpowered build and enemies have chance to give some sort of challenge, but it wouldn't matter much, since how easy to break the game you still will able to melt them through their resistance any ways
You just grew very soft and have expectations of instant gratification.
Second reason why you might think 5min per floor is slow is because how often you get strong dps builds every single time that game gladly provide with tear, damage ups is nearly guranteed
I'm telling from experience when comparing today isaac vs vanilla Rebirth and especially Original The Binding of Isaac
Personally, I think magic mush is fine as is, I don't know about you, but I almost never find the damn thing anywhere in most runs. It's also not insanely game breaking on it's own, yes, it gives a big damage boost, but it doesn't increase tears which is just as, or even more important, then raw damage in many situations, and grabbing it makes other "special" items like brimstone and godhead, much more likely to be rerolled into something else by the game.
I know this seems like a testament but it is the best way to explain to you that none of these items guarantees you the game by itself (the only one for me the chocolate milk and the forgotten since it gives you damage and brutal rank), but if you are still not convinced play with keeper or the lost with magic mushrom and tell me if that item was the key when you kill hush or delirium or if you have only the rebirth to mega satan
To all this you realize that according to your logic not only deven take magic mushrom but also any op item such as mega tears or protopsis that make easy the first levels
the more you play the more complicated it is that good items appear at the beginning (50 games ago that I do not have tech x and at the beginning it always left)
So I came to the conclusion that this topic does not make any sense or is completely wrongly formulated