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- At the start of the run, your main source of damage will be Rotten Baby, (since it's the only familiar that it's damage scales with your damage) so getting Hive Mind is very powerful.
- Dad's Key could be used to escape from tricky rooms or find a secret / super secret room
- Like you said, Some trinkets like Extension Cord and Baby Bender are very useful
Overall, getting a powerful familiar and focusing on defending yourself seems to be the best strategy for this challenge