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Ok, so maybe the best bet is to start Greed and hope the pills in the shop includes Gulp/One makes you larger/etc., and then keep buying just those?
The strength card also works to unlock Huge Growth.
This is how I did the Huge Growth one. Just start with Azazel and enter the curse room, it often has multiple pills.
Also great for knocking down the Blanket and Haemolacria achievement. If the first shop doesn't have a D20, i still peeked the Curse Rooms for beds and silver treasure room for Blod Clot (or i'd see it at the shop and do the first floor to buy it before resetting). You may even get Tech Zero or Jumper Cable as well from breaking greedmode.