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2) Once you get 1 key piece, the chance of getting next angel room becomes mush higher.
3) By hitting spikes in Sacrifice Room, you can become blessed. Once you see the message, chance of getting angel room is, I think, 100%, even if you failed to follow point 1.
4) Hitting spikes in Sacrifice Room a LOT OF times causes angel bosses to spawn, and they drop key pieces.
If you can manage get enough health, using the sacrifice rooms is the most consistant way.
There are also super secret rooms that sometimes have angel statues in them and trigger the boss fights when blown up. You can get key pieces from these.
I've read that each key piece will only spawn once per run, so don't forget to pick any up that you won from a boss, and don't reroll them for angel items.
Weirdest, probably least helpful tip is that if you generate a boss in an angel room with the delirious item and kill it, it will drop a key piece if you haven't already spawned both pieces.
And you can use Dad's Key to unlock the Mega Satan room instead of getting key pieces from angels.